Natural Killer Cell Therapeutics Industry Growth Analysis |
Posted: September 2, 2022 |
The global NK cell therapeutics market is at a very nascent stage. Currently, there is no approved NK cell therapy in the market. Many biopharmaceutical companies are trying to research and develop new immunotherapies, especially NK cell therapies which would be cost-effective and hence, could act as a next-generation medication for cancer and other acute infectious indications. For instance, major players such as Affimed N.V., GC Cell (GC Biopharma corp.), Glycostem Therapeutics B.V., and Takeda Pharmaceutical Company Limited are investing heavily in clinical trials for their respective therapeutic candidates for various indications such as acute myeloid leukemia (AML), B-cell non-Hodgkin’s lymphoma (NHL) - relapsed or refractory, hepatocellular carcinoma (HCC), and peripheral T-cell lymphoma. Increasing funding and investments in research and development is one of the major opportunities in the global NK cell therapeutics market. The global Natural Killer (NK) cell therapeutics market is expected to reach $5,676.1 million in 2032 from $297.2 million in 2024 at a CAGR of 44.59% during the forecast period 2024-2032. The growth in the global NK cell therapeutics market is expected to be driven by the rising in the number of clinical trials and the increasing incidence and prevalence of cancer cases.
Impact of COVID-19 Due to the pandemic, governments across the globe enforced lockdowns which significantly hampered the research and clinical development of NK cell therapeutics. This situation was majorly witnessed till Q2 2021, which created a negative impact on the global NK cell therapeutics market, resulting in a decline in preclinical and clinical trials of the product candidates. The major reason has been the difficulty in patient recruitment for the ongoing clinical trials, which will have an impact on the launch timelines of the drugs. However, it is worth mentioning here that with the ease of restrictions after Q2 2021, the market for NK cell therapy has gained significant momentum and is anticipated to grow during the forecast period 2024-2032. The COVID-19 pandemic has exerted tremendous strain on the research and clinical development of NK cell therapeutics. Companies operating in the field of NK cell therapies have changed their focus on the research and development of drugs used for COVID-19 treatment to help governments and communities establish a new normal across the globe. This has resulted in the delayed launch of emerging therapies due to a shift in priorities on account of the COVID-19 pandemic. In addition, pharmaceutical companies are diverting their financial resources to develop and repurpose existing drug molecules for the prevention and treatment of COVID-19. This strategy has been adopted by most pharmaceutical companies to generate high revenue from the sale of COVID-19 drugs. These factors exert a combinatorial effect on the development and launch of emerging NK therapies.
Market Segmentation Segmentation 1: by Therapy Type In the global NK cell therapeutics market, the NK cell therapy (unmodified) segment is anticipated to dominate the global NK cell therapeutics market during the forecast period and is expected to hold a share of 57.82%. The segment includes the pipeline NK cell therapeutics derived from allogenic or off-the-shelf cancer-killing immunotherapy, which is readily available from cord blood supplies. Segmentation 2: by Pipeline Products In 2032, the global NK cell therapeutics market is estimated to be dominated by MG4101 and is expected to hold a 36.35% share of total NK cell therapeutics market, followed by TAK-007 with the market share of 24.20% of the NK cell therapeutics market in 2032. Segmentation 3: by Indication The B-cell non-Hodgkin’s lymphoma – relapsed or refractory segment is expected to dominate the global NK cell therapeutics market in 2032 due to the rise in B-cell lymphoma patients across the countries and high unmet need in the disease area. Segmentation 4: by Country The U.S. NK cell therapeutics market will be valued at $232.4 million in 2024 and is expected to be the leading market contributor. The growth can be attributed to the increased research and development activities in the country. Demand – Drivers and Limitations Following are the demand drivers for the global NK cell therapeutics market: • Rising Number of Clinical Trials The market is expected to face some limitations too due to the following challenges: • Lack of Specificity and Poor In Vivo Survival of the NK Cells
Recent Developments in the Global NK Cell Therapeutics Market • In April 2022, Affimed N.V. announced data on the dose-escalation study of its innate cell engager AFM24 in patients with EGFR-positive solid tumors. As per the data, AFM24 showed a well-managed safety profile. Key Market Players and Competition Synopsis The companies that are profiled have been selected based on inputs gathered from primary experts and analyzing company coverage, pipeline product portfolio, and market penetration. Some prominent names established in this market are: • Affimed N.V.
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